Grey's Anatomy star Sandra Oh is to leave the show.
The actress, who plays Dr Cristina Yang, will depart at the end of the new season.
She said in a statement to The Hollywood Reporter: "Creatively, I really feel like I gave it my all, and I feel ready to let her go.
"It's such an interesting thing to play a character for so long and to actually get the sense that she wants to be let go as well. [Cristina] wants to be let go, and I am ready to let her go.
"We have to start the process, story-wise, for the Grey's writers to think of why she's going to go."
Grey's creator Shonda Rimes added: "One of the best days of my life as a writer happened the day Sandra Oh walked in my door to audition and forever changed the course of Grey's Anatomy with her brilliant, nuanced portrayal of Cristina Yang.
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